Melania Trump has insisted that her husband is a “gentleman” and the women who allege that he sexually attacked them are lying.
She also said that lewd opinions Donald Trump made about women which were caught on videotape were not acceptable but failed to represent the guy she knows.
The tape prompted dozens of Republicans to lose their support for him.
In the video, Mr Bush, who was subsequently host of NBC’s Access Hollywood, because he is a star which he can push himself on girls, is told by Mr Trump.
Several women accused Mr Trump of sexual assault, which he denies and have since come forward.
“I know he respects women but he is defending himself because they are lies,” Mrs Trump said.
“I believe my husband,” she said. “My husband is kind and he is a gentleman and he would never do that.”
Since the scandal started speaking for the first, Mrs Trump defended her husband’s conduct with girls, saying he had never acted inappropriately over time.
Girls generally approached her husband before her to give him their phone numbers and behave inappropriately, she said.
Reflecting on the 2005 Access Hollywood videotape leaked to the media 10 days past, she said: “I said to my husband that, you know, the language was inappropriate. It is unacceptable.
“And I was surprised, because that is not the man that I understand.”
Mrs Trump issued a statement saying she found the words he talked to be offensive after the taped remarks became public but she accepted his apology.
She believes NBC Billy Bush, who was fired by NBC over the tape, was the chief culprit.
She also justified her husband’s approach of appearing with the girls that have accused former President Bill Clinton of sexual assault.
With three weeks polls show Mr Trump with substantial ground to make up on Democratic rival Hillary Clinton in crucial battleground states.